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The MEME program determined 9 specific putative motifs that contain 14 to 50 residues (Figure 1A

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We assume the value of E Cl to be such that Cl concentration is at equilibrium, that is the Cl synaptic influx and extrusion through KCC2 cancel each other out, this yields where V mean is the time averaged value the membrane potential taken to be V mean = 60 mV

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