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Understanding the source is critical because it informs the entire strategy behind any potential intervention

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The 5-LOX enzyme, found in CD163 + tumor-associated macrophages, promotes the formation of hepatocellular carcinoma (HCC) by generating leukotrienes that augment cancer cell proliferation and stem cell capabilities [275]

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This can lower inflammation and improve tissue health

also found that after fecal microbiota transplantation, the BAs in mice changed, affecting GLP-1 levels through the G protein-coupled bile acid receptor-5 (TGR5) pathway, thereby promoting fat metabolism and energy expenditure, which has a positive effect on preventing obesity (Wang et al., 2023)