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Both C201A and C408A CstBs are inactive in O 2 -consumption

Legend may help: Improve joint lubrication and fluid quality Decrease inflammation within the joint Reduce lameness associated with joint irritation Support smoother, more comfortable movement Legend may be administered intravenously (IV) or directly into the joint (IA) depending on the condition being treated

This results in a reduction in polymorphonuclear neutrophil (PMN) and macrophage (M) infiltration in ovarian tissues, ultimately alleviating the inflammatory response [111]

The corresponding IC50 values for the oxazole derivative 46 with the extended P1 side chain were 35 and 57 nM, respectively (Kokkala et al., 2016)