GLP-1 receptor agonists exert neuroprotective effects primarily by inhibiting microglial activation, the primary effector cells of neuroinflammation, thus reducing the production of proinflammatory cytokines (e.g., TNF- , IL-1) and alleviating inflammatory damage to brain parenchyma
( d-e, j-l ) One-way ANOVA followed by Sidaks multiple comparisons test
Based on its conversion according to body surface area and detection sensitivity, 100 g/300 Ci/kg [3H]BPC157 was used for tritium labeling experiment in rats, 20, 100, and 500 g/kg of BPC157 was used for unlabeled experiment in rats, and 6, 30, and 150 g/kg of BPC157 was used for unlabeled experiment in dogs
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You may feel a slight pinch or warmth at the injection site, but discomfort is minimal
In rare cases, mild gastrointestinal symptoms such as nausea, bloating, or abdominal discomfort may occur