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Stimulation of M3 or M5 mAChRs in T-lymphocytes facilitate the release of Ca 2+ from intracellular stores via inositol trisphosphate (IP 3 ), resulting in calcium release activated (CRAC) channel Ca 2+ influx and sustained [Ca 2+ ] i oscillations which enhances the expression of c-fos and IL-2 [179]

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Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus