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For patients who are naturally B12 deficient, more frequent injections about once a month may be ideal

Avoid freezethaw: Do not refreeze reconstituted solution

Brain Swelling and Vessels Presentation and Counteraction The occluded superior sagittal sinus rapidly develop brain swelling in rat (brain volume proportional with the change of the brain surface area reveals an immediate increase to the 140% over the initial presentation) and peripheral vessels failure (Figure 1, Figure 2, Figure 3 and Figure 4)

This is a mechanistically appealing strategy with strong preclinical support