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A 2023 review in the Journal of Obesity found no evidence that B12 supplementation independently accelerates weight loss in patients taking semaglutide

However, B12 shots offer faster absorption and a quicker onset of action

Anemia in chronic kidney disease

The speed at which a Vitamin B12 shot works can vary depending on several factors, including the individuals level of deficiency, overall health, and the presence of any underlying medical conditions

For example, the thiamine requirement rises during pregnancy to about 1.4 mg/day (vs

Similarly, a meta-analysis of nine observational studies in older adults found low serum vitamin B 12 concentration to be associated with increased risk for depression, with significant association only in women (100)