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Most of the HNSCC patients showed a c-MET mutation profile of Y1235D which was detected in higher incidence [83]

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Anti-inflammatory effect BPC 157 has significant anti-inflammatory activity and can inhibit the release of pro-inflammatory cytokines (such as TNF-, IL-6), thereby alleviating the inflammatory response

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The intrinsic pathway involves increased permeability of the mitochondrial outer membrane, releasing cytochrome c, which binds to Apaf-1 to form an apoptosome, activating caspase-9, and subsequently activating caspase-3, leading to programmed cell death