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Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition

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Both methods generated the same species assignments for 60 ASVs, whereas 11 ASVs were mapped to dissimilar species by the different methods

This often occurs in smokers, people with metabolic disease, heavy alcohol drinkers, as a side effect of certain prescription drugs, rheumatoid arthritis and impaired thyroid function

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It may be an enzyme called NNMT quietly throttling your fat cells' metabolism