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To find relevance to HD, the group used striatal tissues from the SPRDtgHD rat model, which is known to show biphasic changes in dopamine, with early increases followed by later decreases

This strategy is potentially important in the retention of participants who initiate other treatments during the long evoke/evoke+ trials and likely reflects how semaglutide would be used in real-world therapeutic regimens

53 Future Directions and Unanswered Questions Despite recent evidence from clinical trials, key questions remain about the optimal use of GLP-1RAs for HF

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Liu, W.-J