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[23,24,36] Pharmacodynamic and pharmacokinetic differences that occur with age are a second limitation, with variable responses in neonates, children and adults that result from maturation of developmental metabolic and transporter properties

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These problems may be less likely to occur if blood pressure is controlled

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), along with glucose-dependent insulinotropic polypeptide (GIP) and glucagon (GCG) dual or triple receptor agonists that modulate multiple metabolic pathways, have attracted significant scientific interest due to their multifaceted roles in metabolic regulation

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