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The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action

An elevated blood level of LDL (bad) cholesterol is a known risk factor for heart disease

Moreover, long-acting GLP-1 RAs have been approved for the treatment of obesity due to their improved tolerability, safety, and efficacy ( Introduction , previous investigations into GLP-1 RA-related AEs primarily concentrated on gastrointestinal- and tumor-related issues

CASE 2 On june 2006, a 25-year-old mestizo Mexican male presented to the Departamento de Atencin a la Salud, Universidad Autnoma Metropolitana-Xochimilco., Mexico City, Mxico, for evaluation of an pigmented dark-brown macule localized in the right buccal mucosa with evolution time of three months

GLP-1 is an incretin hormone that is responsible for glucose homeostasis and the post-prandial insulinotropic incretin effect