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This ROS surge induces peroxidative damage to membrane lipids and proteins (e.g., band 3, a key cytoskeletal protein), disrupting phospholipid asymmetry and triggering PS externalization (Turpin et al., 2021

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Concurrently, blood-based biomarker tests including the aspartate aminotransferase-platelet ratio index (APRI) and FIB-4 have also been adopted [101]

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