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Our results show that the lipolytic effect of exenatide on WAT is SIRT1 dependent

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Liraglutide reduces cardiac adipose tissue in type 2 diabetes: A secondary analysis of the liraflame randomized placebo-controlled trial

They matter most for diabetes and prediabetes, but they can also be useful for general metabolic health

Another review in 2021 showed similar results in people with type 2 diabetes, with 2 grams daily for at least two weeks promoting modest weight loss

The accumulation of the results of these ongoing cardiovascular outcome trials should be able to answer questions about cardiovascular benefits of GLP-1 RAs that were strongly suggested by previous preclinical and clinical studies and their possibility to lower the excessive cardiovascular burden in patients with T2D