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At the same time, the dopamine released in these circuits reinforces this new learned connection between the feeling of pleasure and the activity that produced it, making it easier to repeat that feel-good activity over and over again

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Protocols that act on underlying hormone production work on longer timelines, weeks rather than hours, because they shift hormone signaling rather than produce an immediate response

This multi-system approach explains why GLP-1 before and after results look so different from traditional diet results

However, no small-molecule GLP-1R agonists are currently available in the market