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Heatmaps generated using Ward clustering and Euclidean distance measurement revealed distinct patterns of protein expression between treated and control groups in both PWA and PNA models
Long-term safety data are still being collected in ongoing Phase 3 trials
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Pooled analysis reported statistically significant effect on total stroke risk[RR=0.83, 95%CI(0.73, 0.95), p =0.005], and its subtypes such as ischemic Stroke [RR=0.83, 95%CI(0.73, 0.95), p =0.008] from treatment with GLP-1RA versus placebo, and have no significant effect on the risk of hemorrhagic stroke[RR=0.83, 95%CI(0.57, 1.20), p =0.31] and retinopathy [RR=1.54, 95%CI(0.74, 3.23), p =0.25] Conclusion: GLP-1RA significantly reduces the risk of ischemic stroke in type 2 diabetics with cardiovascular risk factors
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Las potenciales explicaciones incluyen diferencias en el tipo de pacientes incluidos, la adherencia al tratamiento del estudio, el tamao muestral, la duracin de la exposicin al frmaco y la activacin del receptor GLP1 con una mayor reduccin de HbA1c con anlogos basados en GLP1 humano de accin ms prolongada que con algunos anlogos de exendina 4 de accin corta
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