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If concomitant use is warranted, because respiratory depression may be greater than otherwise expected, decrease the dosage of hydrocodone bitartrate and acetaminophen tablets and/or the muscle relaxant as necessary

A meta-analysis (12 studies, n=15,314) found high circulating TMAO associated with increased diabetes risk (OR=1.89)

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In addition, the mode of action of gabapentinoids has been suggested to involve inhibition of descending serotonergic facilitation, stimulation of descending inhibition, anti-inflammatory actions, and influence on the affective component of pain [23]

Strecker and colleagues retrospectively reviewed data from patients who underwent primary, unilateral THA for osteoarthritis between June 2016 and December 2022