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In this case, the negatively charged NADPH anion with 2 transfers an electron to the methylcobalamin structure at the very beginning of the CASSCF(14,13) geometry optimization, breaking the Co-C bond, similar to the interaction of methylcob(II)alamin with the dissociated homocysteine anion [2]

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Renal function and glycemic response should be monitored periodically, particularly during dose escalation and in patients at increased risk of adverse reactions

Press release, 11 December 2025