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Glutathione synthesis in cancer cells is largely dependent on cysteine, a precursor derived from cysteine, which is transported into the cell via the xCT (SLC7A11) transporter 14

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Despite being originally classified as a non-essential amino acid [32] in healthy individuals [33], abundant evidence suggests that glutamine is essential in specific stress situations such as severe illness, trauma, and overtraining [9, 34,35,36,37,38]