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Patients undergoing GLP-1 treatments have experienced weight loss of up to 22.5% of their body weight, rivalling weight loss from gastric bypass and sleeve gastrectomy surgeries

Interestingly, the results of the SURPASS-5 tell us information about the impressive weight loss observed with TZP in insulin users

The C-domain loops in IGF2 and insulin are shorter and thus cannot reach the CRD, which explains why the CRD of IGF1R is only important for IGF1 binding, but not for IGF2 or insulin binding 24

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