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In summary, the action of valproate in neural systems is complex, with one aspect including downregulation of PKC signaling, which overlaps with symptom amelioration of manic states in animal models, suggesting that modulation of PKC overactivity is a mechanism that is favored by valproate

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Systematic review with network meta-analysis: the comparative effectiveness and safety of interventions in patients with overt hepatic encephalopathy

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