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As a surrogate for peptide integrity, the activity of the fusion molecule was assessed by its ability to activate human GLP-1R in an ex vivo bioassay

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No new safety signals emerged late in the treatment period that were not present early on

In contrast, serine phosphorylation of IRS proteins inhibits this signaling cascade ( The ratio of serine-phosphorylated IRS to total IRS is widely used as a biomarker of insulin resistance in both brain and peripheral tissues