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2009 Jul;8(8):697701

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GLUTATHIONE AS AN ANTIOXIDANT Oxygen radical stress occurs in all aerobic organisms as a result of aerobic metabolism, with intermediates such as superoxide and hydrogen peroxide that lead to further production of oxygen radicals, which can cause lipid peroxidation and disrupt metabolic processes

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The dosage can also play a role, as many patients start on a lower dose that is gradually increased as their skin adapts