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In 2006, PEO Subs issued a first-in-DoD instruction to PMs that required development of plans to encourage primes to include SBIR projects

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However, none of these studies have specifically selected children with mitochondrial dysfunction or disease to study, so it is difficult to know if individuals with ASD and mitochondrial dysfunction would benefit the most from these treatments or whether these treatments are effective for a wider group of children with ASD

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