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Comprehensive treatment, including medications and/or surgery, combined with diet and exercise, has proven to be the most effective approach

After oral administration, N-acetylcysteine undergoes deacetylation in the liver, producing cysteine, which is used as a substrate for glutathione production, which is a potent endogenous antioxidant

Short-chain fatty acids are the primary energy source for the human cells that line the intestine

Endocrine irAEs can be insidious in onset and usually present with hypophysitis with diminished downstream thyroid and adrenal steroid production, or occasionally with severe headache as the pituitary becomes acutely inflamed [28]

In some cases, 10% or more of their muscle mass is lost in about a year, an amount of muscle loss that could equate to roughly 20 years of normal age-related decline

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