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Common side effects include swelling, redness, bruising, and tenderness in the treated area
Moreover, vitamin B12 aids immune regulation, which is crucial for skin disorders involving immune system dysfunction, like eczema, acne, and psoriasis

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Pernicious anemia is also treated with folic acid to help maintain red blood cells
Certain congenital conditions, such as hereditary intrinsic factor defects and congenital vitamin B12 malabsorption (Imerslund-Grsbeck disease), can also cause severe vitamin B12 deficiency