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Patients should contact their healthcare provider if they experience severe or persistent heartburn that does not respond to conservative measures or over-the-counter treatments within 1-2 weeks, as this may indicate more significant gastroesophageal pathology requiring investigation

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To determine the effects of G49 in the different experimental protocols, one-way ANOVA or BrownForsythe Welch ANOVA or KruskalWallis, two-way ANOVA or two-way repeated measures (RM) ANOVA or Mixed-effect analysis tests, followed by Bonferroni or Dunnett T3 or Dunns post hoc tests was carried out