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A 2025 meta-analysis in PMC (covering 36,754 tirzepatide and 106,057 semaglutide participants across multiple studies) confirmed tirzepatides advantage, finding an average 4.23 percentage points greater weight loss with tirzepatide an effect that was both dose- and duration-dependent

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Prolonged use of Vitamin B6 (over 2 months) at high doses exceeding 1g/day can lead to severe peripheral neuropathy, with symptoms including unsteady gait and numbness in the hands and feet

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It is important to note that Mounjaro is available only by prescription