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To induce glycation, sugars including glucose (Glc), fructose (Fru), and ribose (Rib) were employed, in addition to aldehydes such as glyoxal (GO)

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Any animal-model protocol should include defined humane endpoints, veterinary oversight, and IACUC or equivalent ethics-committee approval before initiation

Some patients regained significant weight after stopping treatment, while others maintained their weight loss or continued to lose weight

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