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A randomized controlled trial found that it does not exacerbate RLS and may even improve symptoms in some individuals, likely due to its dopamine-enhancing effects (Bayard et al., 2011)

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Anxiety or restlessness occasionally accompanies nausea or appetite suppression, especially at higher doses

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Another possibly beneficial and important effect of DSIP is its importance in withdrawal from opioids, when, together with exogenously administered morphine, it was able to modulate opioid peptidergic systems, and in chronic pain, where the results of the study stated a significant reduction in pain attacks in patients with chronic pain and depressive states