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I feel better physically but Im more irritable than I used to be. Thats a sentence Ive heard more than once from patients using GLP-1 medications for diabetes or weight management

Some patients experience temporary discomfort that improves with treatment, while others may need ongoing management with orthotics and padding

Training volume is too high More lifting raises cortisol, increases hunger later, and reduces recovery

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stimulation of cAMP production and ligand binding assays) corroborated this concept, which was subsequently gifted a firm foundation by Kebabian and Calnes 1979 review