There's also an open question on whether Pendulum's capsules reliably deliver enough live bacteria to the right part of the gut to reproduce these effects in everyone
Sufficient anesthesia was judged by no toe-pinch reflex or weak toe-pinch response
Diabetes Metab Syndr 19(2):103185 Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T et al (2019) Sarcopenia: revised European consensus on definition and diagnosis
2019;178:11151131.e15
Endogenously, GLP-1 is secreted by intestinal L cells in response to food, and has multiple roles: enhancing insulin secretion (in a glucose-dependent way), reducing glucagon secretion, slowing gastric emptying, increasing feelings of fullness/satiety, and improving glucose disposal in peripheral tissues
These medicines were invented as an alternative way to treat type 2 diabetes because of the drugs capabilities to regulate blood sugar levels and control appetite