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Nat Med 28:911923 Correia AS, Vale N (2022) Tryptophan metabolism in depression: a narrative review with a focus on serotonin and kynurenine pathways

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Properly following dosage recommendations can make a significant difference in results

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Patients should contact their GP or diabetes specialist if they experience: Persistent vomiting preventing adequate fluid intake Severe abdominal pain Signs of dehydration Inability to tolerate any oral intake Symptoms not improving after 23 weeks at a stable dose In cases of intolerable symptoms despite optimisation , temporary dose reduction, switching to an alternative GLP-1 agent, or considering other therapeutic options may be appropriate