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In obese patients, acipimox can inhibit adipose tissue lipolysis by activating protein upregulated in macrophage by INF- (PUMA-G) (also known as the hydroxycarboxylic acid receptor 2 [HCA2] and GPR109a) receptors

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References Abdel-Daim MM, Abdeen A, Jalouli M, Abdelkader A, Megahed A, Alkahtane A, Almeer R, Alhoshani NM, Al-Johani NS, Alkahtani S, Aleya L (2021) Fucoidan supplementation modulates hepato-renal oxidative stress and DNA damage induced by aflatoxin B1 intoxication in rats