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According to FDA prescribing information, constipation occurs in 16-24% of Wegovy patients and 5-17% of Ozempic patients (dose-dependent), while diarrhea occurs in 11-30% of patients across products and doses

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Metabolism 2007;56(8):1118-1123

Most patients begin to lose weight within the first few weeks of starting retatrutide, with noticeable changes typically occurring by the third month of treatment

At this starting dose, appetite suppression may be minimal or absent

Exposure in healthy Chinese subjects was slightly higher than that seen in other populations (including healthy European and Japanese subjects and obese European subjects, Fig