retatrutide resting heart rate increase? : r/Retatrutide Your resting heart rate goes

GLP-1 analog has 97% homology with human GLP-1 and has been approved for the clinical treatment of diabetes and obesity

First introduced in 1927, insulin shock therapy was devised by Manfred Sakel, an Austrian neuropsychologist, after he observed an improvement in the psychiatric condition of one of his patients with a morphine addiction when he recovered from a hypoglycaemic coma accidentally induced by too much insulin

However, these are not instant solutions

All references FDA: Concerns with unapproved GLP-1 drugs used for weight loss NEJM (2023): Retatrutide Phase 2 trial in obesity Eli Lilly: Phase 2 retatrutide results published in NEJM Eli Lilly (Dec 2025): Phase 3 TRIUMPH-4 topline results announcement ClinicalTrials.gov: NCT05882045 (TRIUMPH-3) Drugs.com: Retatrutide status & timeline Lilly Trials: TRIUMPH-3 summary page

Week 5 Focus/Productivity I worked fairly hard at the beginning of the week

The 9mg dose led to 26.4% weight loss