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Inject under the skin (subcutaneously) only

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If you miss two or more consecutive doses of semaglutide, you should restart at a lower dose to minimize gastrointestinal side effects, even if you previously tolerated higher doses well

eClinicalMedicine 69:1 Weiss T et al (2022) Real-world weight change, adherence, and discontinuation among patients with type 2 diabetes initiating glucagon-like peptide-1 receptor agonists in the UK