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The introduction of incretin based therapies, particularly glucagon like peptide 1 receptor agonists, represented a major advance in the management of metabolic disease

W., Freinkman, E., Danai, L

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These data suggest that GLP-1 receptors contribute to the insulinotropic action of glucagon and that in GLP-1R knockout mice there is some extrapancreatic mechanism that compensates for the loss of glucagon-induced insulin secretion via GLP-1R

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Furthermore, the GLP-1RA and DPP-IV inhibitor do not usually bring about hypoglycemia and/or weight gain