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Statistics and reproducibility Statistical significance was determined using independent t -test for immunohistochemical and western blot analyses, and one-way analysis of variance for cell cycle and apoptosis detection by GraphPad Prism 7.0 software (GraphPad, Inc., La Jolla, CA, USA)

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Medicare Advantage and Part D plans may cover Enbrel for people who have moderate to severe disease

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Dosing protocols are based on allometric scaling and anecdotal evidence, which are imperfect guides