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J Clin Endocrinol Metab 109(8):2019-2028

Comparing lean mass loss across semaglutide, tirzepatide, and traditional weight-loss interventions [10:30]

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These effects are usually temporary and mild

Therapeutic implications The biology argues against indiscriminate antioxidant loading. More promising are source- and compartment-targeted strategies (e.g., NOX isoform modulation, mitochondrial quality control, ER stress tuning), buffer re-balancing (GSH/thioredoxin systems), iron management to suppress Fenton chemistry and lifestyle interventions that reshape ROS tone without blunting adaptive signalling