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1 As a direct result of their pain, patients have reported sleep disturbances, impaired activities of daily living, depressed mood, anxiety, and overall diminished quality of life

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The WHI estrogen plus progestin substudy, stratified by age, showed in women 50 to 59 years of age a non-significant trend toward reduced risk for overall mortality [hazard ratio (HR) 0.69 (95 percent CI, 0.44-1.07)]

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They also affect apoptosis by regulating the activity and expression of apoptosis-related proteins