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An already lightweight athlete on semaglutides will have little desire to eat during or outside training, potentially leading to chronic energy deficiency a condition similar to RED-S (Relative Energy Deficiency in Sport) with consequences including fatigue, poor recovery, hormonal disturbances and impaired performance

Further investigations in cell models demonstrated that human GLP1R A316T exhibits characteristics of constitutive activation but dampened GLP-1RA responses

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