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Sig Transduct Target Ther 4 , 45 (2019)

Our finding that several diseases show lowered blood NAD + levels and overall imbalanced redox metabolites is intriguing, as it suggests that a variety of disease processes increase NAD + usage, potentially by activated repair processes including PARP enzymes a major user of NAD +8 .The results have high potential relevance for clinical and research applications, follow-up of metabolic interventions and detection of disease-induced NAD + or glutathione deficiency to select patients for treatment

Hiltz ME, Lipton JM

Both hyperglycemia and dyslipidemia can induce structural and functional damage in diabetic kidneys (Sun et al., 2019)

3.2 Glutathione peroxidase (GPx) activity Back and co-workers reported that spirodioxyselenurane exhibit excellent antioxidant property by mimicking glutathione peroxidise enzyme [47]

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