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Orforglipron also demonstrated superiority over oral semaglutide (Rybelsus) in a head-to-head trial for blood sugar control and weight loss in type 2 diabetes, delivering better results with fewer food and water intake restrictions

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Nilsson JB, Kaabinejadian S, Yari H, Kester MGD, van Balen P, Hildebrand WH, et al

30 Parting Notes Not all drugs have a half-life

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Semaglutide can already reduce appetite for nutrient-dense foods, and acidic substances may further compromise the bioavailability of certain minerals like calcium and magnesium