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Data collection process For each included trial, we used predesigned forms to extract study characteristics, participants demographics and baseline characteristics, and outcome data

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The SELECT trial recruited 17,604 patients with pre-existing CVD and BMI 27 kg/m 2 , but without a history of diabetes

PIONEER 6 PIONEER 6 was a randomized, double-blind, placebo-controlled trial comparing oral semaglutide to placebo designed to rule out an excess in cardiovascular risk with oral semaglutide among patients with T2DM

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