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All published evidence is from animal or in vitro studiesno peer-reviewed human clinical trials have been completed as of 2026

Chemical models, using agents like CCl 4 , diethylnitrosamine, thioacetamide or monosodium glutamate, induce liver fibrosis but do not fully represent the metabolic dysfunctions seen in human MASLD

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EPO is synthesized mainly by the kidney and is released in response to hypoxia into the bloodstream, in which it travels to the bone marrow

547 Metabolic decline of aged astrocytes is also well documented