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A meta-analysis reported a weight loss of 4.19 kg (4.16%), a decrease in body mass index of 1.55 kg/m 2 , and a decrease in waist circumference of 3.11 cm when liraglutide was used [12]

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

This interaction is further complicated by the fact that GLP-1 receptor agonists reduce food intake and body weight in humans, meaning that a physiologically restricted state may more closely resemble the conditions under which these drugs exert their long-term clinical effects

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Your doctor may suggest moving down to or staying on a lower dose