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If you experience unexplained fatigue, kidney discomfort, or changes in urination while taking B12, it might be worth asking about genetic testing for these transport protein variations

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Carmona-Ribeiro, Biocolloids Laboratory, Departamento de Bioqumica, Instituto de Qumica, Universidade de So Paulo, Av

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Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease

35 It is also shown that iron deficiency promotes glycolysis by limiting oxidative metabolism, affecting carbohydrate and fat catabolic processes, and leading to skeletal muscle energy disorders