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Science 310:10221025

Signals for disease modification Evidence for true disease modification remains low-certainty and hypothesis-generating, with recent observational signals serving as a foundation for potential disease modification rather than established therapeutic benefit (100)

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6 Inhibiting IGF-1R with teprotumumab, a mAb, has been shown to reduce the characteristic eye bulging (proptosis) and other serious clinical manifestations in patients with TED