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efficacy for chronic weight management has not been established at lower doses

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T3 increases also the translocation of GLUT4 to the plasma membrane in skeletal muscle and adipose tissue and this might contribute to the hypothyroidism associated impaired glucose tolerance (77)

TRANSCEND-T2D-1 (NCT06354660) will compare the efficacy and safety of retatrutide compared to placebo in people with inadequately controlled T2D treated with diet and exercise over a period of 11 months